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Genetic Toxicology : Current Status of Methods of Carcinogen Identification

By Tennant, Raymond W., Dr.

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Book Id: WPLBN0000679741
Format Type: PDF eBook
File Size: 655,443 KB.
Reproduction Date: 2005

Title: Genetic Toxicology : Current Status of Methods of Carcinogen Identification  
Author: Tennant, Raymond W., Dr.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Disarmament Documents
Publication Date:
Publisher: United Nations - Office for Disarmament Affairs (UNODA)


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Tennant, R. W. (n.d.). Genetic Toxicology : Current Status of Methods of Carcinogen Identification. Retrieved from

Government Reference Publication

Introduction: Genetic toxicology came into existence as a separate discipline in the mid-1960s. The origin of the field was tied to a growing understanding of the mutagenic basis of some cancers and a strong association between radiation, induced mutation, and cancer. Development of the field was also motivated by concerns for the effects of chemicals and environmental factors on the human gene pool and the transmission of induced mutations to subsequent generations. Over a period of approximately 3 decades, the discipline has evolved significantly and has contributed to a clearer understanding of relationships among chemical structure. induced mutae-e nesis. and cancer. Thecon- tributions of genetic toxicology to understanding the role of induced mutations in heritable diseases is covered in another article in this issue by Shelby et al. (I). In this paper we summarize information derived principally from chemicals studied under the aegis of the National Toxicology Program (NTP) and describe relationships between chemical structures and biological effects related to cancer. Wealso discuss in vitro and short-term in vivo methods used for identifying potential mutagens and carcinogens and their value and limitations. In addition, current efforts to improve methods of carcinogen identification and to understand the properties of carcinogenic chemicals that are not mutagenic are summarized.


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